Top 10: February 2021

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By Christian Hoffmann &
Bernd S. Kamps

28 February

Articles of the Day >>>

  • Weekly epidemiological update – 23 February 2021.
  • COVID-19 epidemic in the Brazilian state of Amazonas was driven by long-term persistence of endemic SARS-CoV-2 lineages and the recent emergence of the new Variant of Concern P.1.
  • Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus.
  • Global.health 2021.
  • Massive Google-funded COVID database will track variants and immunity.
  • The same covid-19 mutations are appearing in different places.
  • Computational Fluid Dynamics Modeling of Cough Transport in an Aircraft Cabin. m
  • Inflight Transmission of COVID-19 Based on Experimental Aerosol Dispersion Data
  • Weekly epidemiological update – 23 February 2021.
  • Vaccines and Related Biological Products Advisory Committee February 26, 2021 Meeting Announcement.
  • Longitudinal analysis of SARS-CoV-2 seroprevalence using multiple serology platforms.

 

27 February

Articles of the Day >>>

  • Interleukin-6 Receptor Inhibition in Covid-19 – Cooling the Inflammatory Soup
  • Risk Factors Associated With COVID-19 Transmission Among US Air Force Trainees in a Congregant Setting
  • A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity
  • Effect of previous SARS-CoV-2 infection on humoral and T-cell responses to single-dose BNT162b2 vaccine
  • Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals
  • Bell’s palsy and SARS-CoV-2 vaccines
  • Elevation in viral entry genes and innate immunity compromise underlying increased infectivity and severity of COVID-19 in cancer patients
  • Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19
  • Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia
  • Otolaryngologic Manifestations in Pediatric Inflammatory Multisystem Syndrome Temporally Associated With COVID-19

 

26 February

Articles of the Day >>>

  • BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting
  • COVID-19 Outbreak Among Attendees of an Exercise Facility — Chicago, Illinois, August–September 2020
  • SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates.
  • Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection
  • How to Advise Persons Who Are Antibody Positive for SARS-CoV-2 About Future Infection Risk
  • Blue toes’ following vaccination with the BNT162b2 mRNA COVID-19 vaccine
  • Community Transmission of SARS-CoV-2 at Three Fitness Facilities — Hawaii, June–July 2020
  • Prolonged SARS-CoV-2 cell culture replication in respiratory samples from patients with severe COVID-19
  • Atypical symptoms, SARS-CoV-2 test results, and immunization rates in 456 residents from eight nursing homes facing a COVID-19 outbreak
  • Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study
  • Genome and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21.31 locus associated with severe COVID-19
  • Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19

 

25 February

Articles of the Day >>>

  • Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine induced sera
  • No higher infectivity but immune escape of SARS-CoV-2 501Y.V2 variants
  • Genomic evidence of SARS-CoV-2 reinfection involving E484K spike mutation, Brazil
  • Importance of non-pharmaceutical interventions in lowering the viral inoculum to reduce susceptibility to infection by SARS-CoV-2 and potentially disease severity
  • The use of dried blood spots for the serological evaluation of SARS-CoV-2 antibodies
  • Clinical correlates of anti-SARS-CoV-2 antibody profiles in Spanish COVID-19 patients from a high incidence region
  • Diagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey
  • Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers
  • Use of convalescent serum reduces severity of COVID-19 in nonhuman primates
  • Therapeutic potential of C1632 by inhibition of SARS-CoV-2 replication and viral-induced inflammation through upregulating let-7

 

24 February

Articles of the Day >>>

  • Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients
  • Association of the Timing of School Closings and Behavioral Changes With the Evolution of the Coronavirus Disease 2019 Pandemic in the US
  • Clusters of SARS-CoV-2 Infection Among Elementary School Educators and Students in One School District — Georgia, December 2020–January 2021
  • Difficulties in differentiating coronaviruses from subcellular structures in human tissues by electron microscopy
  • Characteristics and Factors Associated with COVID-19 Infection, Hospitalization, and Mortality Across Race and Ethnicity
  • Onset, duration and unresolved symptoms, including smell and taste changes, in mild COVID-19 infections
  • Sequelae in Adults at 6 Months After COVID-19 Infection
  • Cardiovascular sequalae in uncomplicated COVID-19 survivors
  • Trends in Trauma Admissions During the COVID-19 Pandemic in Los Angeles County, California
  • Prophylactic anticoagulation for patients in hospital with covid-19

 

23 February

Articles of the Day >>>

  • Inflight Transmission of COVID-19 Based on Experimental Aerosol Dispersion Data
  • Analysis of asymptomatic and presymptomatic transmission in SARS-CoV-2 outbreak, Germany, 2020
  • Duration of Culturable SARS-CoV-2 in Hospitalized Patients with Covid-19
  • Comparison of sixteen serological SARS-CoV-2 immunoassays in sixteen clinical laboratories
  • Saliva for molecular detection of SARS-CoV-2 in school-aged children
  • Association of clinical sub-phenotypes and clinical deterioration in COVID-19: further cluster analyses
  • Upper respiratory infections in schools and childcare centers reopening after COVID-19 dismissals, Hong Kong
  • Timing of Rituximab and immunoglobulin level influence the risk of death for COVID-19 in ANCA-associated vasculitis
  • Is Cardiopulmonary Resuscitation Futile in Coronavirus Disease 2019 Patients Experiencing In-Hospital Cardiac Arrest
  • Efficacy and safety of systematic corticosteroids among severe COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials

 

22 February

Articles of the Day >>>

  • SARS-CoV-2 Positivity on or After 9 Days Among Quarantined Student Contacts of Confirmed Cases
  • Reducing contacts to stop SARS-CoV-2 transmission during the second pandemic wave in Brussels, Belgium, August to November 2020
  • Biomechanical Characterization of SARS-CoV-2 Spike RBD and Human ACE2 Protein-Protein Interaction
  • First Month of COVID-19 Vaccine Safety Monitoring — United States, December 14, 2020–January 13, 2021
  • Epidemiology and clinical course of first wave coronavirus disease cases, Faroe Islands
  • Causes of death and comorbidities in hospitalized patients with COVID-19
  • Delayed-onset myocarditis following COVID-19
  • Risk and course of SARS-CoV-2 infection in patients treated for hypothyroidism and hyperthyroidism
  • The potential effect of COVID-19-related disruptions on HIV incidence and HIV-related mortality among men who have sex with men in the USA: a modelling study
  • Prone Positioning and Survival in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Respiratory Failure

 

21 February

Articles of the Day >>>

  • Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials
  • Harnessing peak transmission around symptom onset for non-pharmaceutical intervention and containment of the COVID-19 pandemic
  • Adaptive immunity to SARS-CoV-2 and COVID-19.
  • Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
  • PD-1-Expressing SARS-CoV-2-Specific CD8+ T Cells Are Not Exhausted, but Functional in Patients with COVID-19.
  • Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19
  • Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera.
  • Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020.
  • PD-1-Expressing SARS-CoV-2-Specific CD8+ T Cells Are Not Exhausted, but Functional in Patients with COVID-19.
  • SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model
  • A Phase II Safety and Efficacy Study on Prognosis of Moderate Pneumonia in COVID-19 patients with Regular Intravenous Immunoglobulin Therapy
  • Unleashing the immune system against cancer.
  • Sous la pression du variant anglais, Dunkerque voit flamber l’épidémie de Covid-19.
  • Covid-19 : comment le variant B.1.1.7, apparu en Angleterre, menace de relancer l’épidémie en France.

 

20 February

Articles of the Day >>>

  • Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial
  • Vitamin D3 to Treat COVID-19: Different Disease, Same Answer
  • Covid-19 deaths in Africa: prospective systematic postmortem surveillance study
  • Neutralizing Activity of BNT162b2-Elicited Serum – Preliminary Report
  • Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine – Preliminary Report
  • Early rate reductions of SARS-CoV-2 infection and COVID-19 in BNT162b2 vaccine recipients
  • What does 95% COVID-19 vaccine efficacy really mean
  • Years of life lost to COVID-19 in 81 countries
  • Clinical and Laboratory Findings in Patients with Potential SARS-CoV-2 Reinfection, May-July 2020
  • Severe clinical relapse in an immunocompromised host with persistent SARS-CoV-2 infection

 

19 February

Articles of the Day >>>

  • Circulating SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
  • Evolutionary Dynamics and Dissemination Pattern of the SARS-CoV-2 Lineage B.1.1.33 During the Early Pandemic Phase in Brazil.
  • Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e.
  • Densely sampled viral trajectories suggest longer duration of acute infection with B.1.1.7 variant relative to non-B.1.1.7 SARS-CoV-2.
  • Experimental characterization of speech aerosol dispersion dynamics.
  • SARS-CoV-2 exposure in escaped mink, Utah, USA.
  • Superspreaders drive the largest outbreaks of hospital onset COVID-19 infection.
  • Covid-19: How the lessons of HIV can help end the pandemic.
  • Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children.
  • Unprotected African health workers die as rich countries buy up COVID-19 vaccines.

 

18 February

Articles of the Day >>>

  • Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets.
  • Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677.
  • SARS-CoV-2 variants B.1.351 and B.1.1.248: Escape from therapeutic antibodies and antibodies induced by infection and vaccination.
  • PD-1-Expressing SARS-CoV-2-Specific CD8+ T Cells Are Not Exhausted, but Functional in Patients with COVID-19.
  • Age-related heterogeneity in Neutralising antibody responses to SARS-CoV-2 following BNT162b2 vaccination.
  • COVID vaccines and safety: what the research says.
  • Myocarditis in COVID-19 presenting with cardiogenic shock: a case series.
  • Ocular MRI Findings in Patients with Severe COVID-19: A Retrospective Multicenter Observational Study.
  • A genomic region associated with protection against severe COVID-19 is inherited from Neandertals.
  • Cutaneous findings in SARS-CoV-2-associated Multisystem Inflammatory Disease in Children (MIS-C).
  • Adiós Corona-Tristesse.

 

17 February

Articles of the Day >>>

  • COVID-19 and the human innate immune system.
  • The coronavirus is here to stay — here’s what that means.
  • FAQs on Protecting Yourself from COVID-19 Aerosol Transmission.
  • The role of children in the spread of COVID-19: Using household data from Bnei Brak, Israel, to estimate the relative susceptibility and infectivity of children.
  • Persistence of SARS-CoV-2 specific B- and T-cell responses in convalescent COVID-19 patients 6-8 months after the infection.
  • Some antibodies can dampen antiviral defences in people with severe COVID.
  • Global absence and targeting of protective immune states in severe COVID-19.
  • A preliminary report of a randomized controlled phase 2 trial of the safety and immunogenicity of mRNA-1273 SARS-CoV-2 vaccine.
  • Sixty-day consequences of COVID-19 in patients discharged from hospital: an electronic health records study.
  • Real-time prediction of COVID-19 related mortality using electronic health records.
  • Las nuevas variantes del virus se enfrentan a los más de 100 millones de personas que ya han pasado la covid.
  • La souche historique du SARS-CoV-2 décroît alors que progression du variant britannique s’intensifie.

 

16 February

Articles of the Day >>>

  • Diagnostics for SARS-CoV-2 infections.
  • Factors associated with SARS-CoV-2 infection and outbreaks in long-term care facilities in England: a national cross-sectional survey.
  • Morphometry of SARS-CoV and SARS-CoV-2 particles in ultrathin plastic sections of infected Vero cell cultures.
  • Viral load of SARS-CoV-2 in adults during the first and second wave of COVID-19 pandemic in Houston, TX: the potential of the super-spreader.
  • The COVID-19 Response Has Uncovered and Increased Our Vulnerability to Biological Warfare.
  • What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2.
  • Escaping Catch-22 — Overcoming Covid Vaccine Hesitancy.
  • SARS-CoV-2 re-infection risk in Austria.
  • Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial.
  • Supplements for the Treatment of Mild COVID-19-Challenging Health Beliefs With Science From A to Z.

 

15 February

Articles of the Day >>>

  • Update note on B.1.1.7 severity.
  • Variants – 13 February update.
  • Estimating epidemiologic dynamics from cross-sectional viral load distributions.
  • The Helix® COVID-19 Surveillance Dashboard.
  • Early introductions and community transmission of SARS-CoV-2 variant B.1.1.7 in the United States.
  • Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases.
  • Role of IgG against N-protein of SARS-CoV2 in COVID19 clinical outcomes.
  • The Body Is Far From Helpless Against Coronavirus Variants.
  • Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US-December 14, 2020-January 18, 2021.
  • Life savers: the amazing story of the Oxford/AstraZeneca Covid vaccine.
  • Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study.
  • COVID-19 and the collapse of global trade: building an effective public health response.
  • La endiablada búsqueda de una cura para la covid.
  • Amour et sexualité à l’heure de la Covid-19.

 

14 February

Articles of the Day >>>

  • Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial.
  • Tocilizumab reduces deaths in patients hospitalised with COVID-19,
  • Safety and efficacy of the ChAdOx1 nCoV-19 (AZD1222) Covid-19 vaccine against the B.1.351 variant in South Africa.
  • Emergence of a Novel SARS-CoV-2 Variant in Southern California.
  • Exhaled aerosol increases with COVID-19 infection, age, and obesity.
  • mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants.
  • Vaccine-induced immunity provides more robust heterotypic immunity than natural infection to emerging SARS-CoV-2 variants of concern.
  • Post-traumatic stress disorder symptoms in COVID-19 survivors: online population survey.
  • A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics.

 

13 February

Articles of the Day >>>

  • Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial.
  • Tocilizumab reduces deaths in patients hospitalised with COVID-19,
  • Safety and efficacy of the ChAdOx1 nCoV-19 (AZD1222) Covid-19 vaccine against the B.1.351 variant in South Africa.
  • Emergence of a Novel SARS-CoV-2 Variant in Southern California.
  • Exhaled aerosol increases with COVID-19 infection, age, and obesity.
  • mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants.
  • Vaccine-induced immunity provides more robust heterotypic immunity than natural infection to emerging SARS-CoV-2 variants of concern.
  • Post-traumatic stress disorder symptoms in COVID-19 survivors: online population survey.
  • A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics.

 

12 February

Articles of the Day >>>

  • Public policy and health in the Trump era.
  • Evidence of early circulation of SARS-CoV-2 in France: findings from the population-based “CONSTANCES” cohort.
  • Maximizing Fit for Cloth and Medical Procedure Masks to Improve Performance and Reduce SARS-CoV-2 Transmission and Exposure, 2021.
  • CDC study recommends double masking to reduce Covid-19 exposure.
  • Time-resolved Systems Immunology Reveals a Late Juncture Linked to Fatal COVID-19.
  • Severe reinfection with South African SARS-CoV-2 variant 501Y.V2: A case report.
  • Inhaled budesonide in the treatment of early COVID-19 illness: a randomised controlled trial.
  • Sensitive tracking of circulating viral RNA through all stages of SARS-CoV-2 infection.
  • Association between Clinical Frailty Scale score and hospital mortality in adult patients with COVID-19 (COMET): an international, multicentre, retrospective, observational cohort study.
  • Effect of the new SARS-CoV-2 variant B.1.1.7 on children and young people.

 

11 February

Articles of the Day >>>

  • Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection.
  • Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.
  • Public health actions to control new SARS-CoV-2 variants.
  • Excess mortality associated with the COVID-19 pandemic among Californians 18–65 years of age, by occupational sector and occupation: March through October 2020.
  • SARS-CoV-2 transmission among children and staff in daycare centres during a nationwide lockdown in France: a cross-sectional, multicentre, seroprevalence study.
  • Simulation-based study of COVID-19 outbreak associated with air-conditioning in a restaurant featured.
  • Double Face Masks? N95? Protect Yourself Against New Covid-19 Variants With These Mask Upgrades.
  • Prevalence and Outcomes of SARS-CoV-2 Infection Among Migrant Workers in Singapore.
  • A simple nomogram for predicting failure of non-invasive respiratory strategies in adults with COVID-19: a retrospective multicentre study.
  • Coronavirus Brain Breach.

 

10 February

Articles of the Day >>>

  • Comprehensive mapping of mutations to the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human serum antibodies.
  • Emergence of an early SARS-CoV-2 epidemic in the United States.
  • Public Health Interventions, Epidemic Growth, and Regional Variation of the 1918 Influenza Pandemic Outbreak in a Swiss Canton and Its Greater Regions.
  • The Dangers of Ignoring History Lessons During a Pandemic.
  • Initial real world evidence for lower viral load of individuals who have been vaccinated by BNT162b2.
  • Antibodies elicited by SARS-CoV-2 infection and boosted by vaccination neutralize an emerging variant and SARS-CoV-1.
  • Toward superhuman SARS-CoV-2 immunity?
  • Variant-proof vaccines — invest now for the next pandemic.
  • Cross-sectional Assessment of COVID-19 Vaccine Acceptance Among Health Care Workers in Los Angeles.
  • Rapid coronavirus tests: a guide for the perplexed.
  • Covid-19 : le chemin de croix du vaccin d’AstraZeneca.
  • Covid-19 : faut-il libérer les brevets des vaccins pour en produire plus ?
  • Die unsichtbare Welle.
  • ‘Invisible killer’: fossil fuels caused 8.7m deaths globally in 2018, research finds.

 

9 February

Articles of the Day >>>

  • Decreased SARS-CoV-2 viral load following vaccination.
  • Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera.
  • Transmission of SARS-CoV-2 variants in Switzerland.
  • Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England.
  • SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity.
  • Leveraging the antiviral type-I interferon system as a first line defense against SARS-CoV-2 pathogenicity.
  • Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody.
  • Long-COVID – the nightmare that won’t end – a researcher’s first hand perspective.

 

8 February

Articles of the Day >>>

  • Genomic epidemiology identifies emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States.
  • ChAdOx1 nCov-19 provides minimal protection against mild-moderate COVID-19 infection from B.1.351 coronavirus variant in young South African adults.
  • Prevalence of SARS-CoV-2 in Karnataka, India.
  • Factors associated with the spatial heterogeneity of the first wave of COVID-19 in France: a nationwide geo-epidemiological study.
  • Seroprevalence and risk factors of exposure to COVID-19 in homeless people in Paris, France: a cross-sectional study.
  • Integrated immune dynamics define correlates of COVID-19 severity and antibody responses.
  • Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial.
  • The impact of the COVID-19 lockdown on HIV care in 65 South African primary care clinics: an interrupted time series analysis.
  • Arquitectura de un supercontagio: cómo el virus se instaló dos semanas en un edificio de Bilbao.
  • Grippe, gastro ou bronchite : les mesures anti-Covid-19 ont éteint presque toutes les autres épidémies hivernales.
  • «Psychologiquement déstabilisante, la pandémie de Covid-19 a renforcé le complotisme».
  • La pandémie de Covid-19 creuse le fossé en Europe, entre le Sud dépendant du tourisme et le Nord.

 

7 February

Articles of the Day >>>

  • Estimating real-world COVID-19 vaccine effectiveness in Israel.
  • Efficacy of ChAdOx1 nCoV-19 (AZD1222) Vaccine Against SARS-CoV-2 VOC 202012/01 (B.1.1.7).
  • Variants – 6 February update.
  • Risks prediction of COVID-19 incidence and mortality in a large multi-national haemodialysis cohort: Implications for management of the pandemic in outpatient haemodialysis settings.
  • Cardiac arrest in COVID-19: characteristics and outcomes of in- and out-of-hospital cardiac arrest. A report from the Swedish Registry for Cardiopulmonary Resuscitation.
  • Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children.
  • COVID’s mental-health toll: how scientists are tracking a surge in depression.

 

6 February

Articles of the Day >>>

  • SARS-CoV-2 evolution during treatment of chronic infection.
  • How viruses shape our world
  • Estimated seroprevalence of SARS-CoV-2 antibodies among adults in Orange County, California.
  • Nasopharyngeal SARS-CoV-2 viral loads in young children do not differ significantly from those in older children and adults.
  • COVID-19 immune features revealed by a large-scale single cell transcriptome atlas.
  • Patterns of covid-19 pandemic dynamics following deployment of a broad national immunization program.
  • Saliva is more sensitive than nasopharyngeal or nasal swabs for diagnosis of asymptomatic and mild COVID-19 infection.
  • Comparative cost-effectiveness of SARS-CoV-2 testing strategies in the USA: a modelling study.
  • COVID-19 Outcomes Among Persons Living With or Without Diagnosed HIV Infection in New York State.
  • Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study.
  • Coronapod: Variants – what you need to know.
  • The Shapeshifting Virus.

 

5 February

Articles of the Day >>>

  • Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents.
  • Age groups that sustain resurging COVID-19 epidemics in the United States.
  • SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: a prospective cohort study.
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  • Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape.
  • . SARS-CoV-2 B.1.1.7 escape from mRNA vaccine-elicited neutralizing antibodies.
  • Single Dose Administration, And The Influence Of The Timing Of The Booster Dose On Immunogenicity and Efficacy Of ChAdOx1 nCoV-19 (AZD1222) Vaccine.
  • Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial.
  • Vaccine Innovations — Past and Future.

 

4 February

Articles of the Day >>>

  • Transmission of COVID-19 in 282 clusters in Catalonia, Spain: a cohort study.
  • Understanding the drivers of transmission of SARS-CoV-2.
  • Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01 – Technical briefing 5.
  • It’s Time: The COVID Tracking Project Will Soon Come to an End.
  • Pandemic Vaccines: How Are We Going to Be Better Prepared Next Time?
  • Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.
  • The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity.
  • Immune determinants of COVID-19 disease presentation and severity.
  • Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail.
  • Single Dose Vaccination in Healthcare Workers Previously Infected with SARS-CoV-2.
  • Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
  • Azithromycin, RECOVERY, and the power of large, simple trials.

 

3 February

Articles of the Day >>>

  • Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia.
  • Sputnik V COVID-19 vaccine candidate appears safe and effective.
  • Robust spike antibody responses and increased reactogenicity in seropositive individuals after a single dose of SARS-CoV-2 mRNA vaccine.
  • Had Covid? You May Need Only One Dose of Vaccine, Study Suggests.
  • Immunogenic BNT162b vaccines protect rhesus macaques from SARS-CoV-2.
  • Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01 – Technical briefing 5.
  • SARS-CoV-2 persistence is associated with antigen-specific CD8 T-cell responses.
  • Sixteen novel lineages of SARS-CoV-2 in South Africa.
  • PCR assay to enhance global surveillance for SARS-CoV-2 variants of concern.
  • Why some coronavirus variants are more contagious—and how we can stop them.

 

2 February

Chapter Variants | Over the last two months, several new SARS-CoV-2 variants have been described that are more transmissible, may escape both natural and vaccine-induced immunity and could impact COVID-19 morbidity and mortality. It is too early to assert that these variants will create a new pandemic within the pandemic, however, in countries like England, South Africa, Brazil, Ireland, Portugal and Israel, they may have modified the dynamic of the latest outbreaks for the worse. More transmissible SARS-CoV-2 variants will replace older variants – everywhere! Countries where the prevalence of these new variants is still low should anticipate rapid spread within the next weeks and months and plan ahead accordingly, ie closing/restricting borders, etc.

The current trio infernale:

>>> More

 

1 February

No Tops Today

No Top 10 papers today because we were busy finishing a new chapter. Can you imagine what it will be about? If you are familiar with the topic, you will immediately recognize some of the illustrations in the following preview of the 35 pages. Rendez-vous tomorrow evening.

 

 

In the meantime, you might wish to

See you tomorrow evening!

BSK + CH


>>> January 2021


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The COVID Reference Top 10

By Christian Hoffmann &
Bernd S. Kamps

Copy-editor: Rob Camp.