Top 10: July 2020

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By Christian Hoffmann &
Bernd S. Kamps

 31 July

The Top 10 >>>

  • Body Mass Index and Risk for Intubation or Death in SARS-CoV-2 Infection
  • Activation and evasion of type I interferon responses by SARS-CoV-2
  • Epidemiology of invasive pulmonary aspergillosis among COVID-19 intubated patients: a prospective study

and more >>>

30 July

The Top 10 >>>

  • Comparison of Face-Touching Behaviors Before and During the Coronavirus Disease 2019 Pandemic
  • Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
  • Assessment of Community-Level Disparities in Coronavirus Disease 2019 (COVID-19) Infections and Deaths in Large US Metropolitan Areas

and more >>>

29 July

The Top 10 >>>

  • SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19 (Nature)
  • Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates (N Engl J Med)
  • Case characteristics, resource use, and outcomes of 10 021 patients with COVID-19 admitted to 920 German hospitals: an observational study (Lancet Respir Med )

and more >>>

28 July

The Top 10 >>>

  • Longitudinal analyses reveal immunological misfiring in severe COVID-19
  • Estimation of Viral Aerosol Emissions From Simulated Individuals With Asymptomatic to Moderate Coronavirus Disease 2019
  • Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19)

and more >>>

 

27 July

The Top 10 >>>

  • Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network
  • Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion
  • Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy

and more >>>

26 July

The Top 10: Clinical >>>

Today, revise what you have studied over the past months. A summary of articles about clinical manifestations, comorbidities and severe COVID-19 since the beginning.

more >>>

25 July

The Top 10 >>>

  • Structural basis of RNA cap modification by SARS-CoV-2
  • COVID-19: immunopathogenesis and Immunotherapeutics
  • Particle sizes of infectious aerosols: implications for infection control

and more >>>

24 July

The Top 10 >>>

  • 4th Edition: Covid Reference España
  • Investigation of a superspreading event preceding the largest meat processing

23 July

The Top 10 >>>

  • Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike
  • Virus-host interactome and proteomic survey of PBMCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis
  • The Contribution of the Age Distribution of Cases to COVID-19 Case Fatality Across Countries – A 9-Country Demographic Study
  • Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients

and more >>>

22 July

The Top 10 >>>

  • Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study
  • Distinct conformational states of SARS-CoV-2 spike protein
  • Feasibility of Separate Rooms for Home Isolation and Quarantine for COVID-19 in the United States

and more >>>

21 July

The Top 10 >>>

  • Outcomes of COVID-19 in Patients with CLL: A Multicenter, International Experience
  • Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System
  • The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study

and more >>>

20 July

The Top 10 >>>

  • Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial.
  • Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial.
  • Clinical Manifestations and Outcomes of Critically Ill Children and Adolescents with COVID-19 in New York City

and more >>>

19 July

The Top 10 >>>

  • Kind request to authors of scientific papers

The Top 10 >>>

18 July

The Top 10 >>>

  • Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report
  • Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
  • The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity

and more >>>

17 July

The Top 10 >>>

  • Universal Masking to Prevent SARS-CoV-2 Transmission—The Time Is Now
  • Magnitude and kinetics of anti-SARS-CoV-2 antibody responses and their relationship to disease severity
  • Aging immunity may exacerbate COVID-19

and more >>>

16 July

The Top 10 >>>

  • An mRNA Vaccine against SARS-CoV-2 – Preliminary Report
  • Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
  • Physical distancing interventions and incidence of coronavirus disease 2019: natural experiment in 149 countries

and more >>>

15 July

Today, there will be no Top 10, but the Top 1,000:

We dedicate this book to our students. May this selection of approx. 1,000 fine articles and full-text links deepen their understanding of the new coronavirus and prepare them for the challenges ahead (PDF, 390 pages).

Download PDF (390 pages)

14 July

The Top 10 >>>

  • Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.
  • Structural basis of a shared antibody response to SARS-CoV-2
  • Potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria in low-income and middle-income countries: a modelling study

and more >>>

13 July

The Top 10 >>>

  • Cardiac manifestations in COVID-19 patients – A systematic review
  • Types of Assays for SARS-CoV-2 Testing: A Review
  • Decontamination and reuse of N95 filtering facemask respirators: a systematic review of the literature
  • That Escalated Quickly: Remdesivir’s Place in Therapy for COVID-19

and more >>>

12 July

The Top 10 >>>

  • Characteristics of Persons Who Died with COVID-19 — United States
  • Blood cell counts and lymphocyte subsets of patients admitted during the COVID-19 pandemic
  • The inside story of the RECOVERY trial

and more >>>

11 July

The Top 10 >>>

  • Persistent Symptoms in Patients After Acute COVID-19 (Jama)
  • Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 (Science Immunology)
  • Coagulation disorder in COVID-19 (Lancet Immunology)

 

and more >>>

 

10 July

The Top 10 >>>

  • COVID-19: the worst may be yet to come
  • Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers
  • Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

and more >>>

9 July

The Top 10 >>>

  • The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings
  • Coronavirus disease among persons with sickle cell disease
  • California’s San Quentin prison declined free coronavirus tests and urgent advice — now it has a massive outbreak
  • Potential transmission of SARS-CoV-2 on a flight from Singapore to Hanghzou, China
  • OpenSAFELY: factors associated with COVID-19 death in 17 million patients

and more >>>

 

8 July

The Top 10 >>>

  • Coronavirus disease exposure and spread from nightclubs, South Korea
  • Kinetics of viral load and antibody response in relation to COVID-19 severity
  • COVID-19 Among Workers in Meat and Poultry Processing Facilities

and more >>>

 

7 July

The Top 10 >>>

  • It is Time to Address Airborne Transmission of COVID-19
  • Human IgG neutralizing monoclonal antibodies
  • Developing a SARS-CoV-2 Vaccine at Warp Speed
  • Seroprevalence of SARS-CoV-2 Among Frontline Healthcare Personnel
  • Obesity and COVID-19 in New York City

and more >>>

6 July

The Top 10 >>>

  • SARS-CoV-2 seroprevalence in COVID-19 hotspots
  • COVID-19 and arterial hypertension
  • Interleukin-6 blockade with sarilumab

and more >>>

5 July

The Top 10 >>>

  • Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics
  • Exaggerated risk of transmission of COVID-19 by fomites
  • Asymptomatic SARS-CoV-2 infection in Belgian long-term care facilities

and more >>>

4 July

The Top 10 >>>

  • Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques
  • Stability of SARS-CoV-2 and other coronaviruses in the environment and on common touch surfaces and the influence of climatic conditions: a review
  • COVID-19 in health-care workers in three hospitals in the south of the Netherlands: a cross-sectional study
  • Evolution of Altered Sense of Smell or Taste in Patients With Mildly Symptomatic COVID-19

and more >>>

 

3 July

The Top 10 >>>

Among other topics, how to safely reopen colleges and universities during COVID-19¸ screening for SARS-CoV-2 infection within a psychiatric hospital; virolactia in an asymptomatic mother; impact of for SARS-CoV-2 viral load on risk of intubation and mortality among hospitalized patients with coronavirus disease 2019; and high proportion of asymptomatic SARS-CoV-2 infections in 9 long-term care facilities.

The Top 10 >>>

2 July

The Top 10 >>>

Among other topics, Next Generation Sequencing of T and B cell receptor repertoires; excess deaths from COVID-19 and other causes; protracted ketonaemia in hyperglycaemic emergencies; neurologic and radiographic findings associated with COVID-19 infection in children; and is a “cytokine storm” relevant to COVID-19?

The Top 10 >>>

 

1 July

The Top 10 >>>

Bouhaddou M, Memon DF, Meyer B, et al. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell June 28, 2020.

Nothing to do next weekend? Then read this incredible work of 66 pages (> 400 references!). In brief: proteomics approaches that globally quantify changes in protein abundance and phosphorylation represent a powerful tool to elucidate mechanisms of viral pathogenesis by providing a snapshot of how cellular pathways and processes are rewired upon infection. Using a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, the 78 (!) authors present the global phosphorylation and protein abundance landscape of SARS-CoV-2 infection, map phosphorylation changes to disrupted kinases and pathways, and use these profiles to find drugs with the potential to treat SARS-CoV-2 infection. In total, 87 compounds (10 FDA-approved drugs) were identified.

The Top 10 >>>

 

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