COVID Reference Daily Top 10 Papers

31 October

Transmission of SARS-COV-2 Infections in Households — Tennessee and Wisconsin, April–September 2020 +++ COVID-19 human challenge studies in the UK +++ Risk of hospital admission with coronavirus disease 2019 in healthcare workers and their households:...

Household transmission

| 31 October | Important study (because prospective). After enrollment, 101 index patients and 191 household members were trained remotely by study staff members to complete symptom diaries and obtain self-collected specimens, nasal swabs...

+++ Treatment +++

| 31 October | Find the entire treatment chapter of the 5th edition at https://covidreference.com/treatment | Corticosteroids – Remdesivir Famotidine Acalabrutinib – Anticomplement therapies – Azithromycin – Camostat – Chloroquine – Colchicine – Convalescent plasma...

++ Español ++

Purgatorio | 31 de octubre | Si lees español, lee Los médicos en las UCI: “Aún no es el infierno, pero sí el purgatorio”. El País 2020, published 31 October | Una cuarta parte...

++ The Textbook ++

| Treatment | 31 October 2020 | Let’s face reality: at the beginning of the second pandemic wave, we have some steroids which have been shown to reduce mortality in patients with severe COVID-19;...

SARS-CoV-2 viremia and mortality

SARS-CoV-2 viral loads, especially plasma viremia, are associated with increased risk of mortality. This is the result of a study by Jonathan Li, Jesse Fajnzylber and colleagues who report SARS-CoV-2 respiratory tract, plasma, and...

++ Pandemic Autumn ++

France lockdown | 28 October | The dramatic second COVID-19 wave in France has lead Emmanuel Macron to announce a new lockdown in the country. The November lockdown which is due to last at...

+++ Vaccines +++

| 27 October 2020 | Brilliant review of SARS-CoV-2 vaccines by Florian Krammer: vaccine platforms, results from studies on non-human primates and results from phase 1/2 trials in humans. Read the review this evening...

Case Fatality Rate (CFR)

The country-specific crude case fatality rates (CFR), the percentage of COVID-19-associated deaths among confirmed SARS-CoV-2 infections, have been the subject of much speculation. There are still striking differences between countries. According to worldometer.com accessed...

+++ Transmission +++

SARS-CoV-2 transmission on an aircraft | 25 October 2020 | Honestly, if you had seen this selection of seats, wouldn’t you have felt safe? This was a 7.5 h flight into Ireland, with a passenger...

+++ Severe COVID-19 +++

Ventilation management and clinical outcomes | 24 October | Retrospective observational study at 18 intensive care units in the Netherlands, with a detailed analysis of 553 patients who received mechanical ventilation during the first...

Tocilizumab: No benefit

Tocilizumab was not effective for preventing intubation or death in moderately ill hospitalized patients with Covid-19. This is the result of a randomized, double-blind, placebo-controlled trial involving SARS-CoV-2 patients with hyperinflammatory states and at...

Saliva: the future of mass screening

Could saliva be the future of mass screening? In his comment on the paper by Isao Yokota et al. we presented on September 29, Lorenzo Azzi highlights the potential merits of saliva: it can...

Host vs. Virus

Only a small proportion of patients with SARS-CoV-2 infection have respiratory compromise, a respiratory distress syndrome, and multiorgan failure. Who is to blame, the virus or the host? To help answer this question, Andre...

Born to SARS-CoV-2+ Mothers

Don’t separate SARS-CoV-2 positive mothers from their newborns and let them breastfeed their kids. This recommendation, already published by Italian pediatricians in June, has now been confirmed by a study of 101 neonates. Two...

SARS CoV-2 transmission in music clubs

Article of the day – and bad news for music clubs: asymptomatically infected persons can transmit the virus as soon as 2 days after infection. Substantial exposure can even occur within a few hours....

Cytokine storm

Daniel Leisman and colleagues question the role of a cytokine storm in COVID-19-induced organ dysfunction after a systematic review and meta-analysis of 25 COVID-19 studies (n=1245 patients) and four trials each in sepsis (n=5320),...

Solidarity Trial: Hydroxychloroquine, Remdesivir etc.

Will remdesivir soon join the hydroxychloroquine and lopinavir graveyard? Interim results from the Solidarity Therapeutics Trial, coordinated by the World Health Organization, indicate that remdesivir, hydroxychloroquine, lopinavir and interferon regimens appear to have little...

Top 10 Special: Transmission

The 5th COVID Reference Edition will be published this month. These are 12 papers we will include in the Transmission chapter.  Find more about ‘spit happens’, aerosolized fomites, leisure transmission venues and choir super-spreading....

Cracking molecular processes

A Science paper by 200 researchers. The authors from six countries uncovered molecular processes used by coronaviruses MERS, SARS-CoV1 and SARS-CoV2 to manipulate host cells. They found 73 human proteins with which components of...

Paris under Curfew

As we disclosed yesterday, the French President Emmanuel Macron has announced this evening a 9 p.m. – 6 a.m. curfew of at least four weeks (see the comment on the paper by Andronico et...

Curfews against COVID

Could curfews be a less costly alternative, both economically and socially, to complete lockdowns? In French Guiana, an overseas départment, a combination of curfews and targeted lockdowns in June and July 2020 was sufficient...

Top 10 Special: Epidemiology

Later this month, we will publish the 5th COVID Reference Edition. Find 10 papers we will include in the Epidemiology chapter. The topics: “variolation”; introduction of SARS-CoV-2 in Europe, North America and Brazil; seroprevalence...

Virulence factor Nsp1

A major virulence factor of SARS-CoV is the non-structural protein 1 (Nsp1) which suppresses host gene expression by ribosome association (see our July 18 CR Top 10: Thoms M, Buschauer R, Ameismeier M, et...

Crowds and COVID

The dynamic of the current SARS epidemics in the Greater Paris and Madrid are reason for concern. In this article, Moritz Kraemer, Benjamin Rader and colleagues predict that crowded cities worldwide could experience more...

Common cold and COVID

The four endemic coronaviruses (eCoV: HCoV-OC43, -HKU1, -NL63, and -229E), the most common etiologic agents for the seasonal “common cold”, share sequence homology with SARS-CoV-2. Here, Joseph Mizgerd, Manish Sagar and colleagues show that...