We dedicate this book to our students. May this selection of approx. 1,000 fine articles and full-text links deepen their understanding of the new coronavirus and prepare them for the challenges ahead (390 pages).
We dedicate this book to our students. May this selection of approx. 1,000 fine articles and full-text links deepen their understanding of the new coronavirus and prepare them for the challenges ahead (PDF, 390 pages).
8 August
The daily Top 10 papers will be presented throughout the day.
(Never go to bed without reading them.)
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19 (Nature)
Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates (N Engl J Med)
Case characteristics, resource use, and outcomes of 10 021 patients with COVID-19 admitted to 920 German hospitals: an observational study (Lancet Respir Med )
Today, revise what you have studied over the past months. A summary of articles about clinical manifestations, comorbidities and severe COVID-19 since the beginning.
Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study
Distinct conformational states of SARS-CoV-2 spike protein
Feasibility of Separate Rooms for Home Isolation and Quarantine for COVID-19 in the United States
Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial.
Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial.
Clinical Manifestations and Outcomes of Critically Ill Children and Adolescents with COVID-19 in New York City
Today, there will be no Top 10, but the Top 1,000:
We dedicate this book to our students. May this selection of approx. 1,000 fine articles and full-text links deepen their understanding of the new coronavirus and prepare them for the challenges ahead (PDF, 390 pages).
Among other topics, how to safely reopen colleges and universities during COVID-19¸ screening for SARS-CoV-2 infection within a psychiatric hospital; virolactia in an asymptomatic mother; impact of for SARS-CoV-2 viral load on risk of intubation and mortality among hospitalized patients with coronavirus disease 2019; and high proportion of asymptomatic SARS-CoV-2 infections in 9 long-term care facilities.
Among other topics, Next Generation Sequencing of T and B cell receptor repertoires; excess deaths from COVID-19 and other causes; protracted ketonaemia in hyperglycaemic emergencies; neurologic and radiographic findings associated with COVID-19 infection in children; and is a “cytokine storm” relevant to COVID-19?
Bouhaddou M, Memon DF, Meyer B, et al. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell June 28, 2020.
Nothing to do next weekend? Then read this incredible work of 66 pages (> 400 references!). In brief: proteomics approaches that globally quantify changes in protein abundance and phosphorylation represent a powerful tool to elucidate mechanisms of viral pathogenesis by providing a snapshot of how cellular pathways and processes are rewired upon infection. Using a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, the 78 (!) authors present the global phosphorylation and protein abundance landscape of SARS-CoV-2 infection, map phosphorylation changes to disrupted kinases and pathways, and use these profiles to find drugs with the potential to treat SARS-CoV-2 infection. In total, 87 compounds (10 FDA-approved drugs) were identified.
