COVID Reference International

The COVID Textbook by
Kamps & Hoffmann

1. The Book


4th edition, PDF, 330 pages

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2. New Chapters

21 September: Flu vaccine

6 September: Prevention

24 August: Top 20 on Face Masks

3. Daily Science: Top 10

Every day (Monday, Tuesday, Wednesday, Thursday, Friday, Saturday, Sunday) you will find the Top 10 Scientific Papers of the Day.

N Engl J Med, Lancet, Nature, Science, Cell, Emerg Infect Dis, etc.

4. Daily Science: The Top 10 Book


PDF, 636 pages, 19 September

Daily Science


5. Online Chapters

More than 1.000 full-text links to scientific articles:

  1. Epidemiology
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  5. Immunology
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6. Languages (n=8)







Tiếng Việt


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Vorwort | Zeitachse | Epidemiologie | Virologie | Immunologie | Diagnose | Klinik | Therapie | Schwerer Krankheitsverlauf | Komorbiditäten | Pädiatrie

Wichtiger Hinweis

Español (PDF)

Prefacio | Cronología | Epidemiología | Virología | Inmunología | Diagnóstico | Manifestación clínica | Tratamiento | COVID-19 severo | Comorbilidades | Pediatria

Descargo de responsabilidad

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Préface | Chronologie | Virologie | Épidémiologie | Immunologie | Diagnostic | Présentation clinique | Traitement | Formes sévères de COVID-19 | Comorbidités | Pediatrie


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Prefazione | Cronologia | Epidemiologia | Virologia | Immunologia | Diagnosi | Manifestazione clinica | Terapia | COVID-19 severo | Comorbidità | Pediatria


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Prefácio | Cronologia | Epidemiologia | Virologia | Imunologia | Diagnóstico | Apresentação clínica | Tratamento | COVID-19 grave | Comorbilidades/Populações Especiais | Pediatria e gravidez

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Tiếng Việt (PDF)

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Tuyên bố miễn trừ trách nhiệm

Türkçe (PDF)

Önsöz | Süreç | Epidemioloji | Viroloji | Iimmünoloji | Teşhis Testleri ve Prosedürleri | Klinik sunum | Tedavi Yöntemleri | Şiddetli COVID-19 | Komorbiditeler | Çocuk Sağlığı





Daily Science: Top 10

Home | TOP 10 BOOK (PDF) | April | May | June | July | August

By Christian Hoffmann &
Bernd S. Kamps


Daily Science
The Top 10 Book
Update 19 September
Volume 1: Jan-Sep
636 pages, PDF
Volume 2:
November – April 2021

21 September

The following text will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give it early visibility.

Top 10 Special

Vaccinate for seasonal influenza

By Stefano Lazzari

Several authors (Richmond 2020, Jaklevic 2020, Singer 2020, Rubin 2020, Maltezoua 2020) and public health agencies are recommending expanding seasonal flu vaccination in the context of the COVID-19 pandemic. This follows concerns about the potential “double epidemic” of COVID-19 and seasonal flu during the winter months (Balakrishnan 2020, Gostin 2020).

See the entire text (+ 26 references) >>>


Source: Servick K. How will COVID-19 affect the coming flu season? Scientists struggle for clues. Science 2020, published 14 August. Full-text: https://www.sciencemag.org/news/2020/08/how-will-covid-19-affect-coming-flu-season-scientists-struggle-clues. Reproduced with permission.


20 September

The Top 10 >>>

  • Molecular architecture of the SARS-CoV-2 virus
  • Transmission of severe acute respiratory syndrome coronavirus 2 during long flight
  • Viral Load Predicts Mortality in Patients with and Without Cancer Who Are Hospitalized with COVID-19

and more >>>

19 September


After more than six months of studying the scientific COVID-19 literature you might wish to take a break. What if you did something completely different? For example, learning a few Italian words. The Covid Reference team has prepared for you a fine free package of audio files and PDFs. (Even a cellphone app!)

Enjoy: http://4Elisa.com/Audio !

The Top 10 >>>

  • Ultrasensitive high-resolution profiling of early seroconversion in patients with COVID-19
  • Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay
  • A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS)

and more >>>

18 September

The Top 10 >>>

  • Transmission of SARS-CoV-2: A Review of Viral, Host, and Environmental Factors
  • Association of Daily Wear of Eyeglasses With Susceptibility to Coronavirus Disease 2019 Infection
  • A history of herd immunity

and more >>>

17 September

The Top 10 >>>

  • Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing
  • Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong
  • Seasonal coronavirus protective immunity is short-lasting

and more >>>

16 September

The Top 10 >>>

  • Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition.
  • Frequency of Children vs Adults Carrying Severe Acute Respiratory Syndrome Coronavirus 2 Asymptomatically
  • SARS-CoV-2–Associated Deaths Among Persons Aged <21 Years — United States, February 12–July 31, 2020

and more >>>

15 September

The Top 10 >>>

  • The lasting misery of coronavirus long-haulers
  • Every Body Counts: Measuring Mortality From the COVID-19 Pandemic
  • Characteristics, Comorbidities, and Outcomes in a Multicenter Registry of Patients with HIV and Coronavirus Disease-19

and more >>>

14 September

The Top 10 >>>

Lost and Found or “The Zebra Fish Collection”

Crazy times – we are approaching 50.000 COVID-19 citations on PubMed. These days publishing must go fast, sometimes even faster, sometimes too fast. Here we present 10 examples.

and more >>>

13 September

The Top 10 >>>

  • SARS-CoV-2 transmission via speech-generated respiratory droplets
  • Racial/Ethnic Variation in Nasal Gene Expression of Transmembrane Serine Protease 2 (TMPRSS2)
  • Postdischarge thrombosis and hemorrhage in patients with COVID-19

and more >>>


12 September

The Top 10 >>>

  • German national team of amateur boxers: 100% transmission within days
  • Prevalence of Underlying Medical Conditions Among Selected Essential Critical Infrastructure Workers
  • Reduced maximal aerobic capacity after COVID-19 in young adult recruits, Switzerland, May 2020

and more >>>

11 September

The Top 10 >>>

  • The emergence of SARS-CoV-2 in Europe and North America
  • The coding capacity of SARS-CoV-2
  • A neutrophil activation signature predicts critical illness and mortality in COVID-19

and more >>>

10 September

The Top 10 >>>

  • Clinical Outcomes in Young US Adults Hospitalized With COVID-19
  • Incidence of Nosocomial COVID-19 in Patients Hospitalized at a Large US Academic Medical Center
  • De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

and more >>>

9 September

The Top 10 >>>

  • The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19
  • Facial Masking for Covid-19 — Potential for “Variolation” as We Await a Vaccine
  • Development of Transverse Myelitis after Vaccination. A CDC/FDA Vaccine Adverse Event Reporting System (VAERS) Study, 1985–2017
  • Detection of SARS-CoV-2 RNA in Blood of Patients with COVID-19: What Does It Mean?

and more >>>

8 September

The Top 10 >>>

  • Ultra-sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease
  • Association between SARS-CoV-2 neutralizing antibodies and commercial serological assays
  • Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

and more >>>

7 September

The Top 10 >>>

  • CR4 Việt Nam (290 pages)
  • Infection Fatality Ratios for COVID-19 Among Noninstitutionalized Persons 12 and Older: Results of a Random-Sample Prevalence
  • High potency of a bivalent human VH domain in SARS-CoV-2 animal models

and more >>>

6 September

The Top 10 >>>

  • Symptomatic SARS-CoV-2 reinfection by a phylogenetically distinct strain
  • Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2
  • Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

and more >>>

5 September

The Top 10 >>>

  • Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia.
  • Accumulating evidence suggests anti-TNF therapy needs to be given trial priority in COVID-19 treatment
  • SARS-CoV-2 specific T-cell responses and correlations with COVID-19 patient predisposition

and more >>>

4 September

The Top 10 >>>

  • Community Outbreak Investigation of SARS-CoV-2 Transmission Among Bus Riders in Eastern China
  • A molecular trap against COVID-19
  • An ID Doctor’s Confrontation with His Own Case of COVID-19 – An Interview with Dr. Michael Saag

and more >>>

3 September

The Top 10 >>>

  • Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19
  • Corticosteroids for COVID-19 – New Evidence of Benefit
  • Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

and more >>>

2 September

The Top 10 >>>

  • Probable Evidence of Fecal Aerosol Transmission of SARS-CoV-2 in a High-Rise Building.
  • Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques
  • . Visualizing droplet dispersal for face shields and masks with exhalation valves featured

and more >>>

1 September

The Top 10 >>>

  • Tracking the COVID-19 pandemic in Australia using genomics
  • Clinical Characteristics and Viral RNA Detection in Children With Coronavirus Disease 2019 in the Republic of Korea
  • Annals On Call – Regulatory T Cells: Treatment for COVID-19?

and more >>>


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