Top 10: November 2020

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By Christian Hoffmann &
Bernd S. Kamps

30 November

Articles of the Day >>>

  • Surviving COVID-19 After Hospital Discharge: Symptom, Functional, and Adverse Outcomes of Home Health Recipients
  • Corticosteroids for COVID-19: the search for an optimum duration of therapy
  • Probability of Success and Timelines for the Development of Vaccines for Emerging and Reemerged Viral Infectious Diseases


29 November

Articles of the Day >>>

  • Public needs to prep for vaccine side effects
  • Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: nationwide seroepidemiological study
  • Where has all the influenza gone? The impact of COVID-19 on the circulation of influenza and other respiratory viruses, Australia, March to September 2020


28 November

Articles of the Day >>>

  • SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication
  • DeepCOVID-XR: An Artificial Intelligence Algorithm to Detect COVID-19 on Chest Radiographs Trained and Tested on a Large US Clinical Dataset
  • The effect of clinical decision making for initiation of systemic anticancer treatments in response to the COVID-19 pandemic in England: a retrospective analysis


27 November

Articles of the Day >>>

  • WHO recommends against the use of remdesivir in COVID-19 patients
  • Deciphering the ins and outs of SARS-CoV-2-specific T cells
  • Clinical, Laboratory, and Interferon-Alpha Response Characteristics of Patients With Chilblain-like Lesions During the COVID-19 Pandemic


26 November

Articles of the Day >>>

  • Rethinking Covid-19 Test Sensitivity — A Strategy for Containment
  • No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2
  • Delaying Pregnancy during a Public Health Crisis — Examining Public Health Recommendations for Covid-19 and Beyond


25 November

Articles of the Day >>>

  • A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia
  • Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2
  • The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro


24 November

Articles of the Day >>>

  • Assessment of 135 794 Pediatric Patients Tested for Severe Acute Respiratory Syndrome Coronavirus 2 Across the United States
  • Seroconversion in Emergency Professionals at an Urban Academic Emergency Department in New York City
  • Functional SARS-CoV-2-specific immune memory persists after mild COVID-19


23 November

Articles of the Day ^>>>

  • Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes
  • SARS-CoV-2 mRNA vaccines foster potent antigen-specific germinal center responses associated with neutralizing antibody generation
  • SARS-CoV-2 transmission between mink (Neovison vison) and humans, Denmark


22 November

Articles of the Day >>>

  • Comprehensive health assessment three months after recovery from acute COVID-19
  • Evaluation of the Incidence and Potential Mechanisms of Tracheal Complications in Patients With COVID-19
  • Trends in County-Level COVID-19 Incidence in Counties With and Without a Mask Mandate — Kansas, June 1–August 23, 2020


21 November

Articles of the Day >>>

  • COVID-19 Outbreak Associated with a 10-Day Motorcycle Rally in a Neighboring State — Minnesota, August–September 2020.
  • Host genetic susceptibility to viral infections: the role of type I interferon induction
  • An enhanced isothermal amplification assay for viral detection


20 November

Articles of the Day >>>

  • Recurrent mutations in SARS-CoV-2 genomes isolated from mink point to rapid host-adaptation
  • COVID-19 vaccines: no time for complacency
  • Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers


19 November

Articles of the Day >>>

  • Immunological memory to SARS-CoV-2 assessed for greater than six months after infection
  • Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19
  • Rapid Response to an Outbreak in Qingdao, China


18 November

Articles of the Day >>>

  • Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18–59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial
  • Prognostic Impact of Prior Heart Failure in Patients Hospitalized With COVID-19
  • Impact of COVID-19 Pandemic on Mechanical Reperfusion for Patients With STEMI


17 November

Articles of the Day >>>

  • Multiple COVID-19 Outbreaks Linked to a Wedding Reception in Rural Maine — August 7–September 14, 2020
  • SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but are Not Enriched in β Cells
  • COVID-19, Decarceration, and the Role of Clinicians, Health Systems, and Payers. A Report From the National Academy of Sciences, Engineering, and Medicine


16 November

Articles of the Day >>>

  • Sixty-Day Outcomes Among Patients Hospitalized With COVID-19
  • Neutralization by Intravenous Immunoglobulins Produced From Plasma Collected Before the 2020 Pandemic
  • Spike-specific circulating T follicular helper cell and cross-neutralizing antibody responses in COVID-19-convalescent individuals


15 November

Articles of the Day >>>

  • Susceptibility to Sars-COV-2 Infection Among Children And Adults: A Seroprevalence Study of Family Households in the Barcelona Metropolitan Region, Spain
  • Three-month pulmonary function and radiological outcomes in COVID-19 survivors: a longitudinal patient cohort study
  • Vitamin D Deficiency Is Inversely Associated with COVID-19 Incidence and Disease Severity in Chinese People


14 November

Articles of the Day >>>

  • COVID-19 and diabetes mellitus: from pathophysiology to clinical management
  • Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells
  • Predicting airborne coronavirus inactivation by far-UVC in populated rooms using a high-fidelity coupled radiation-CFD model


13 November

Articles of the Day >>>

  • SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo
  • Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19A Randomized Clinical Trial
  • Seroprevalence of anti–SARS-CoV-2 IgG antibodies in Kenyan blood donors


12 November

Articles of the Day >>>

  • Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19
  • An outbreak of Covid-19 on an aircraft carrier
  • The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity


11 November

Articles of the Day >>>

  • Mobility network models of COVID-19 explain inequities and inform reopening
  • Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2
  • Covid-19 vaccines: Should we allow human challenge studies to infect healthy volunteers with SARS-CoV-2?


10 November

The Top 10 >>>

  • What Pfizer’s landmark COVID vaccine results mean for the pandemic
  • Association Between Nursing Home Crowding and COVID-19 Infection and Mortality in Ontario, Canada
  • Randomized, double-blinded and placebo-controlled phase II trial of an inactivated SARS-CoV-2 vaccine in healthy adults


9 November

The Top 10 >>>

  • Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
  • COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice
  • Case Study: Prolonged infectious SARS-CoV-2 shedding from an asymptomatic immunocompromised cancer patient


8 November

The next Top 10 will be presented tomorrow. In the meantime, please take a look at two revised chapters of the 5th edition:



AcalabrutinibAzithromycinCamostatChloroquineColchicineConvalescent plasmaCorticosteroidsCytokine blockersFamotidineFavipiravirG-CSFHuman recombinant soluble ACE2HydroxychloroquineIbrutinibIloprostInterferonsJAK inhibitorsLeflunomideLopinavirMonoclonal antibodiesN-acetylcysteineOseltamivirProtease inhibitorsRdRp inhibitorsREGN-COV2Umifenovir

Outlook | References

Find the entire treatment chapter at


Comorbidities : Introduction | Hypertension / CVD | Diabetes mellitus | COPD and smoking | HIV infection | Immunosuppression | Cancer | Transplantation | Other comorbidities


7 November

No Top 10 today, but the 5th Edition, 486 pages. | Preface: “Second waves, third waves, never ending waves – as the world is about to enter the second year of the SARS-CoV-2 pandemic, people realize that they are just at the beginning of a global health and economic crisis. In the Northern Hemisphere, the 6 dark autumn and winter months have begun and the world is holding its breath: will the new coronavirus follow the track of the 1918 flu epidemic, relatively mild in spring and devastating in autumn and winter?” | Free download.


6 November

The Top 10 >>>

  • Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2
  • An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
  • De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2


5 November

The Top 10 >>>

  • Regional and global contributions of air pollution to risk of death from COVID-19
  • Longitudinal monitoring of SARS-CoV-2 RNA on high-touch surfaces in a community setting
  • We Need to Talk About Ventilation


4 November

The Top 10 >>>

  • Compromised humoral functional evolution tracks with SARS-CoV-2 mortality
  • Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection
  • Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production


3 November

The Top 10 >>>

  • SARS-CoV-2 seroprevalence and transmission risk factors among high-risk close contacts: a retrospective cohort study
  • Interferon deficiency can lead to severe COVID
  • COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms


2 November

The Top 10 >>>

  • Characterization of Myocardial Injury in Patients With COVID-19
  • Mild or Moderate Covid-19
  • Addition of Corticosteroids to Immune Globulins is Associated with Recovery of Cardiac Function in Multi-inflammatory Syndrome in Children (MIS-C)


1 November

The Top 10 >>>

  • The Low Case Fatality Rate of COVID-19 in Hong Kong Could Be Deceptive
  • Modeling the load of SARS-CoV-2 virus in human expelled particles during coughing and speaking
  • Declining prevalence of antibody positivity to SARS-CoV-2: a community study of 365 000 adults


>>> October 2020

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The COVID Reference Top 10

By Christian Hoffmann &
Bernd S. Kamps

Copy-editor: Rob Camp.