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By Christian Hoffmann &
Bernd S. Kamps
30 November
- Surviving COVID-19 After Hospital Discharge: Symptom, Functional, and Adverse Outcomes of Home Health Recipients
- Corticosteroids for COVID-19: the search for an optimum duration of therapy
- Probability of Success and Timelines for the Development of Vaccines for Emerging and Reemerged Viral Infectious Diseases
29 November
- Public needs to prep for vaccine side effects
- Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: nationwide seroepidemiological study
- Where has all the influenza gone? The impact of COVID-19 on the circulation of influenza and other respiratory viruses, Australia, March to September 2020
28 November
- SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication
- DeepCOVID-XR: An Artificial Intelligence Algorithm to Detect COVID-19 on Chest Radiographs Trained and Tested on a Large US Clinical Dataset
- The effect of clinical decision making for initiation of systemic anticancer treatments in response to the COVID-19 pandemic in England: a retrospective analysis
27 November
- WHO recommends against the use of remdesivir in COVID-19 patients
- Deciphering the ins and outs of SARS-CoV-2-specific T cells
- Clinical, Laboratory, and Interferon-Alpha Response Characteristics of Patients With Chilblain-like Lesions During the COVID-19 Pandemic
26 November
- Rethinking Covid-19 Test Sensitivity — A Strategy for Containment
- No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2
- Delaying Pregnancy during a Public Health Crisis — Examining Public Health Recommendations for Covid-19 and Beyond
25 November
- A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia
- Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2
- The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro
24 November
- Assessment of 135 794 Pediatric Patients Tested for Severe Acute Respiratory Syndrome Coronavirus 2 Across the United States
- Seroconversion in Emergency Professionals at an Urban Academic Emergency Department in New York City
- Functional SARS-CoV-2-specific immune memory persists after mild COVID-19
23 November
- Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes
- SARS-CoV-2 mRNA vaccines foster potent antigen-specific germinal center responses associated with neutralizing antibody generation
- SARS-CoV-2 transmission between mink (Neovison vison) and humans, Denmark
22 November
- Comprehensive health assessment three months after recovery from acute COVID-19
- Evaluation of the Incidence and Potential Mechanisms of Tracheal Complications in Patients With COVID-19
- Trends in County-Level COVID-19 Incidence in Counties With and Without a Mask Mandate — Kansas, June 1–August 23, 2020
21 November
- COVID-19 Outbreak Associated with a 10-Day Motorcycle Rally in a Neighboring State — Minnesota, August–September 2020.
- Host genetic susceptibility to viral infections: the role of type I interferon induction
- An enhanced isothermal amplification assay for viral detection
20 November
- Recurrent mutations in SARS-CoV-2 genomes isolated from mink point to rapid host-adaptation
- COVID-19 vaccines: no time for complacency
- Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers
19 November
- Immunological memory to SARS-CoV-2 assessed for greater than six months after infection
- Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19
- Rapid Response to an Outbreak in Qingdao, China
18 November
- Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18–59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial
- Prognostic Impact of Prior Heart Failure in Patients Hospitalized With COVID-19
- Impact of COVID-19 Pandemic on Mechanical Reperfusion for Patients With STEMI
17 November
- Multiple COVID-19 Outbreaks Linked to a Wedding Reception in Rural Maine — August 7–September 14, 2020
- SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but are Not Enriched in β Cells
- COVID-19, Decarceration, and the Role of Clinicians, Health Systems, and Payers. A Report From the National Academy of Sciences, Engineering, and Medicine
16 November
- Sixty-Day Outcomes Among Patients Hospitalized With COVID-19
- Neutralization by Intravenous Immunoglobulins Produced From Plasma Collected Before the 2020 Pandemic
- Spike-specific circulating T follicular helper cell and cross-neutralizing antibody responses in COVID-19-convalescent individuals
15 November
- Susceptibility to Sars-COV-2 Infection Among Children And Adults: A Seroprevalence Study of Family Households in the Barcelona Metropolitan Region, Spain
- Three-month pulmonary function and radiological outcomes in COVID-19 survivors: a longitudinal patient cohort study
- Vitamin D Deficiency Is Inversely Associated with COVID-19 Incidence and Disease Severity in Chinese People
14 November
- COVID-19 and diabetes mellitus: from pathophysiology to clinical management
- Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells
- Predicting airborne coronavirus inactivation by far-UVC in populated rooms using a high-fidelity coupled radiation-CFD model
13 November
- SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo
- Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19A Randomized Clinical Trial
- Seroprevalence of anti–SARS-CoV-2 IgG antibodies in Kenyan blood donors
12 November
- Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19
- An outbreak of Covid-19 on an aircraft carrier
- The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity
11 November
- Mobility network models of COVID-19 explain inequities and inform reopening
- Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2
- Covid-19 vaccines: Should we allow human challenge studies to infect healthy volunteers with SARS-CoV-2?
10 November
- What Pfizer’s landmark COVID vaccine results mean for the pandemic
- Association Between Nursing Home Crowding and COVID-19 Infection and Mortality in Ontario, Canada
- Randomized, double-blinded and placebo-controlled phase II trial of an inactivated SARS-CoV-2 vaccine in healthy adults
9 November
- Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
- COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice
- Case Study: Prolonged infectious SARS-CoV-2 shedding from an asymptomatic immunocompromised cancer patient
8 November
The next Top 10 will be presented tomorrow. In the meantime, please take a look at two revised chapters of the 5th edition:
Treatment
Acalabrutinib – Azithromycin – Camostat – Chloroquine – Colchicine – Convalescent plasma – Corticosteroids – Cytokine blockers – Famotidine – Favipiravir – G-CSF – Human recombinant soluble ACE2 – Hydroxychloroquine – Ibrutinib – Iloprost – Interferons – JAK inhibitors – Leflunomide – Lopinavir – Monoclonal antibodies – N-acetylcysteine – Oseltamivir – Protease inhibitors – RdRp inhibitors – REGN-COV2 – Umifenovir
Find the entire treatment chapter at https://covidreference.com/treatment
Comorbidities
Comorbidities : Introduction | Hypertension / CVD | Diabetes mellitus | COPD and smoking | HIV infection | Immunosuppression | Cancer | Transplantation | Other comorbidities
7 November
No Top 10 today, but the 5th Edition, 486 pages. | Preface: “Second waves, third waves, never ending waves – as the world is about to enter the second year of the SARS-CoV-2 pandemic, people realize that they are just at the beginning of a global health and economic crisis. In the Northern Hemisphere, the 6 dark autumn and winter months have begun and the world is holding its breath: will the new coronavirus follow the track of the 1918 flu epidemic, relatively mild in spring and devastating in autumn and winter?” | Free download.
6 November
- Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2
- An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
- De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2
5 November
- Regional and global contributions of air pollution to risk of death from COVID-19
- Longitudinal monitoring of SARS-CoV-2 RNA on high-touch surfaces in a community setting
- We Need to Talk About Ventilation
4 November
- Compromised humoral functional evolution tracks with SARS-CoV-2 mortality
- Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection
- Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production
3 November
- SARS-CoV-2 seroprevalence and transmission risk factors among high-risk close contacts: a retrospective cohort study
- Interferon deficiency can lead to severe COVID
- COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms
2 November
- Characterization of Myocardial Injury in Patients With COVID-19
- Mild or Moderate Covid-19
- Addition of Corticosteroids to Immune Globulins is Associated with Recovery of Cardiac Function in Multi-inflammatory Syndrome in Children (MIS-C)
1 November
- The Low Case Fatality Rate of COVID-19 in Hong Kong Could Be Deceptive
- Modeling the load of SARS-CoV-2 virus in human expelled particles during coughing and speaking
- Declining prevalence of antibody positivity to SARS-CoV-2: a community study of 365 000 adults
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The COVID Reference Top 10
By Christian Hoffmann &
Bernd S. Kamps
Copy-editor: Rob Camp.