Category: COVID Reference

+++ Treatment +++

Blog 3 December WHO Solidarity Trial Consortium. Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results. N Engl J Med 2020, published 2 December. Full-text: https://doi.org/10.1056/NEJMoa2023184 Harrington DP, Baden LR, Hogan JW...

+++ Vaccines +++

Blog 3 December WHO Ad Hoc Expert Group on the Next Steps for Covid-19 Vaccine Evaluation.  Placebo-Controlled Trials of Covid-19 Vaccines — Why We Still Need Them. N Engl J Med 2020, published 2...

+++ Diagnosis +++

Blog 3 December Dugdale CM, Anahtar MN, Chiosi JJ, et al. Clinical, laboratory, and radiologic characteristics of patients with initial false-negative SARS-CoV-2 nucleic acid amplification test results. Open Forum Infect Dis 2020, published 24...

+++ Virology +++

Blog 1 Dezember Popa A, Genger JW, Nicholson MD. Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2. Science Translational Medicine 23 November 2020: eabe2555. Full-text: https://doi.org/10.1126/scitranslmed.abe2555 Alexandra...

+++ Immunology +++

Blog 2 Dezember Agarwal V, Venkatakrishnan AJ, Puranik A et al. Long-term SARS-CoV-2 RNA shedding and its temporal association to IgG seropositivity. Cell Death Discov. 6, 138 December 2, 2020. Full-text: https://doi.org/10.1038/s41420-020-00375-y A retrospective...

+++ Clinical Manifestation +++

Blog 2 Dezember Cao A, Rohaut B, Guennec LL, et al. Severe COVID-19-related encephalitis can respond to immunotherapy. Brain December 2, 2020. Full-text: https://doi.org/10.1093/brain/awaa337 See title (“can” respond). The authors report a case series...

7 Days

The daily Top 10 – every day the best papers published in the best medical and scientific journals. By Christian Hoffmann & Bernd S. Kamps. Copy-editor: Rob Camp.   30 November Epidemiology Vos ERA,...

+++ Epidemiology +++ x

29 November Trieu MC, Bansal A, Madsen A, et al. SARS-CoV-2-specific neutralizing antibody responses in Norwegian healthcare workers after the first wave of COVID-19 pandemic: a prospective cohort study. J Infect Dis. 2020 Nov...

+++ Severe COVID-19 +++

Blog 29 November Knoouhuizen SA, Aday A, Lee WM. Ketamine‐Induced Sclerosing Cholangitis (KISC) in a Critically Ill Patient with COVID‐19. Hepatology 23 November 2020. Full-text: https://doi.org/10.1002/hep.31650 Prior reports of recreational ketamine abuse have been...

+++ Pediatrics +++

Blog 2 Dezember Lee EH, Kepler KL, Geevarughese A, et al. Race/Ethnicity Among Children With COVID-19–Associated Multisystem Inflammatory Syndrome. JAMA Netw Open November 30, 2020;3(11):e2030280. Full-text: https://doi.org/10.1001/jamanetworkopen.2020.30280 Distribution of race/ethnicity among 223 MIS-C cases...

+++ Prevention +++

29 November Vogel G, Couzin-Frankel J. Grade: incomplete. Science 27 November 2020: Vol. 370, Issue 6520, pp. 1023-1027. Full-text: https://doi.org/10.1126/science.370.6520.1023 Schools around the world are again the site of a large, and largely uncontrolled,...

+++ Comorbidities +++

Blog 24 November Yu B, Li C, Sun Y, et al. Insulin treatment is associated with increased mortality in patients with COVID-19. Cell Metabolism November 23, 2020. Full-text: https://doi.org/10.1016/j.cmet.2020.11.014 Oops! In this retrospective study...

+++ Education +++

+++ Education +++

13 November Rubin EJ, Baden LR, Morrissey S. An Update from Operation Warp Speed. Audio interview (28:20). N Engl J Med 2020; 383: e127. Access: https://doi.org/%2010.1056/NEJMe2033111 The editors discuss the pace of discovery in...

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5th International Edition | 7 November | Finally, after five months, we have published the next edition of COVID Reference – The COVID Textbook (486 pages; we apologize for the delay). We will keep...