Top 10: April 2020

20 – 26 April

Beispiel für die Wochenzusammenfassung am Sonntag Abend:

One of this week’s highlights was the study by Salje et al., Estimating the burden of SARS-CoV-2 in France. As of May 11, the projected beginning of the de-confinement in France, 5.7% of the French population would have been infected. This proportion would vary from region to region. In the Greater-Paris area or in Alsace, the most affected regions, the immunization rate might be as high as 12% on average, but less than 2% in New Aquitaine, Brittany or Pays de la Loire.

In a second study by Pinco and Pallino…

The third winner of this week is the review by Hinz und Kunz…

20 April

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Today, discover a phantastic overview about current knowledge and the pathways leading to cytokine release syndrome, a report of five patients with COVID-19–associated Guillain–Barré syndrome, a paper on neurological complications which are probably due to an aberrant immune response, and an animal study showing that SARS-CoV-2-infected macaques provide a new model to test therapeutic strategies.

Furthermore, you’ll find that the tighter you control the infected, the less restriction you have to impose on the uninfected and that mass masking  for  source  control  is  a  useful  and   low-cost   adjunct   to   social   distancing   and   hand   hygiene. You’ll be advised not to stop your sartans or ACE inhibitors and find guidance for management of inflammatory bowel disease during the COVID-19.

Finally, it’s still age. A Multivariate analysis of a retrospective cohort of 1590 hospitalized subjects with COVID-19 throughout China revealed the following factors associated with mortality: age 75 or, age 65-74 years, coronary heart disease, cerebrovascular disease, dyspnea,  procalcitonin>0.5ng/ml, AST>40 U/L. Nothing truly new, the paper reports the largest cohort so far.

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13-19 April

19 April

18 April

17 April

16 April

15 April

14 April

13 April

6-12 April

This week